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FIGURE 3 TPPU and DHA + TPPU Decrease Inflammation in the Hippocampus of Diabetic Rats An increase in the neuroinflammation was evident in the hippocampus of diabetic rats due to the rise in the level of pro-inflammatory marker IL-1 (Figure 4A) (412 29 pg/ml) and IL-6 (Figure 4B) (180 6 pg/ml) and decrease in the level of anti-inflammatory marker IL-10 (Figure 4C) (220 7 pg/ml) in comparison to the healthy normal rats (IL-1, 311 14 pg/ml

What this means for clinical research: Clinical development in 2026 is increasingly geographically modular, requiring sponsors and CROs to coordinate multi-region strategies earlier and manage data, quality, and regulatory alignment across jurisdictions

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